RARE Nature Magazine Human Genome Foldout February 2001 Vol 409 Issue 6822

  
This Nature issue captures a pivotal moment in science - the first unveiling of the human genetic code and. Is highly significant and valuable. Let me know if you have any questions. Feature: The Human Genome Foldout. Condition: Rare Collectible Very Good. This issue of Nature Magazine contains the first publication of the draft human genome sequence by the International Human Genome Sequencing Consortium. This was a landmark achievement in biology and medicine, providing the first comprehensive look at the human genome.

Includes a detailed foldout of "The Geography of Our Genome". The issue reveals groundbreaking scientific findings, including. The human genome contains only 30,000-40,000 genes, far fewer than the 100,000 previously estimated. Insights into human evolution and the organization of the genome. The first analysis of how the genome is structured and functions.

These discoveries transformed our understanding of human biology and laid the foundation for the genomic revolution in medicine and biotechnology. As a pivotal historical document in science, original copies of this Nature issue have become highly prized by collectors. Key features that make it valuable include.

It contains the first publication of the draft human genome sequence. It includes a foldout poster titled "The Geography of Our Genome". It represents a defining moment in scientific history, comparable to the publication of Darwin's "On the Origin of Species". The open release of the human genome sequence catalyzed a new era of biological and medical research. It provided a foundation for studying genetic contributions to human health and disease, enabled new fields like personalized medicine, and accelerated the pace of genomic discovery across biology.

In summary, this Nature issue captures a pivotal moment in science - the first unveiling of the human genetic code. Its scientific, historical and cultural significance, combined with its tangible features like the genome poster, make original copies highly sought after by collectors and institutions.

It stands as a symbol of one of the greatest scientific achievements in human history. Human genomes, public and private. The burgeoning commercial sector that is based on genome information poses a challenge to the norms of scientific publication. But it remains to be established that the conditions of access to published sequence data need to change. Patents in a genetic age. The present patent system risks becoming a barrier to medical progress. The road to the code. And the cast who brought genetics to centre stage. An excavation of the drug myth. One who created a tempo of his own.

Biologists must take responsibility for the correct use of language in genetics. The draft sequences of the human genome are remarkable achievements. They provide an outline of the information needed to create a human being and show, for the first time, the overall organization of a vertebrate's DNA. Clone by clone by clone. The public project's sequencing strategy involved producing a map of the human genome, and then pinning sequence to it.

This helps to avoid errors in the sequence, especially in repetitive regions. Two rough drafts of the human genome sequence are now published.

Completion of the sequences lies ahead, but the implications for studying human diseases and for biotechnology are already profound. Comparing the human genome sequences with those of other species will not only reveal what makes us genetically different. It may also help us understand what our genes do. Single nucleotide polymorphisms are the bread-and-butter of DNA sequence variation. They provide a rich source of information about the evolutionary history of human populations.

To a future of genetic medicine. Single base differences between human genomes underlie differences in susceptibility to, or protection from, a host of diseases. Hence the great potential of such information in medicine. Guide to the draft human genome. Mining the draft human genome.

Keeping time with the human genome. Rossella Tupler Giovanni Perini Michael R.

Learning about addiction from the genome. A genomic view of immunology.

A genomic perspective on membrane compartment organization. Genomics, the cytoskeleton and motility. Can sequencing shed light on cell cycling? Evolutionary analyses of the human genome.

Wen-Hsiung LiZhenglong Gu Anton Nekrutenko. Andrew Futreal Arek Kasprzyk Michael R.

Gerardo Jimenez-Sanchez Barton Childs David Valle. Computational comparison of two draft sequences of the human genome. Initial sequencing and analysis of the human genome. Collections: The 1000 Genomes Project 40 years of Sanger sequencing.

Experimental annotation of the human genome using microarray technology. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Ravi Sachidanandam David Weissman David Altshuler. Collection: The 1000 Genomes Project.

A physical map of the human genome. McPherson Marco Marra Hans Lehrach. The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X.

A physical map of the human Y chromosome. A high-resolution map of human chromosome 12. Montgomery Eunice Lee Raju Kucherlapati.

A physical map of human chromosome 14. Thomas Brüls Gabor Gyapay Roland Heilig. Integration of telomere sequences with the draft human genome sequence. Comparison of human genetic and sequence-based physical maps.

Adong Yu Chengfeng Zhao James L. Integration of cytogenetic landmarks into the draft sequence of the human genome.

The BAC Resource Consortium V.